Fluoride-calcium compositions, dental products, and methods for providing dental fluoride

摘要

Disclosed are dental compositions and methods. In accordance with one embodiment, a dental composition includes calcium, fluorine, which is generally present in the form of fluoride, and phosphate or another stabilizing anion. The composition is stable as against precipitation of calcium fluoride during transport and storage, but is unstable against the precipitation of calcium fluoride in the oral cavity of a human. In many embodiments, the amount of fluoride may be less than the amount of fluoride used in a comparable composition intended for a similar purpose. A dental method comprises applying the composition to the oral cavity of a patient, whereupon calcium fluoride precipitates from the composition.

主权项

1. A dental composition comprising calcium, at least 100 ppm of fluoride, and a stabilizing anion of phosphate glycerophosphate, or phosphonoacetate, the molar ratio of fluoride to calcium being at most 2:1 and the molar ratio of fluoride to the stabilizing anion being at most 30:1, said composition (i) being sufficiently stable to inhibit precipitation of calcium fluoride during an aging test comprising storage at 50° C. in a sealed container for 1 week, (ii) being sufficiently unstable in a human oral cavity to cause precipitation of calcium fluoride, and (iii) not being sufficiently stable to inhibit precipitation of calcium fluoride during said aging test in the absence of said stabilizing anion.