Nucleic acids encoding a human monoclonal antibody that specifically binds to IL-1α

摘要

Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.

主权项

1. A set of isolated nucleic acids comprising a first nucleic acid encoding the heavy chain of a human IgG1 monoclonal antibody (mAb) that specifically binds to human interleukin-1 alpha (IL-1α), and a second nucleic acid encoding the light chain of the human IgG1 mAb that specifically binds to human IL-1α, wherein the first nucleic acid encodes the amino acid sequence of SEQ ID NO: 9 and the second nucleic acid encodes the amino acid sequence of SEQ ID NO: 11.