UN METODO PARA LA PREPARACION DE ESTERES 7-NITRO-8-HIDROXI-QUINOLINICOS.

摘要

1299753 Nitroquinoline derivatives RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SAS 28 Jan 1970 [10 Feb 1969] 4092/70 Heading C2C Novel compounds I (in which X is a valency bond or an aliphatic hydrocarbon group and R is H or a substituted or unsubstituted aryl or heterocyclic group) are prepared by esterifying a 7-nitro-8-hydroxyquinoline with the chloride or anhydride of an acid of Formula R-X-COOH. 7-Nitro-8-hydroxy-quinoline is prepared by hydrolysing 7 - nitro - 8 - hydroxy - quinoline- 5-sulphonic acid which is itself prepared by nitrating 8-hydroxy-quinoline-5-sulphonic acid Some 5,7 dinitro - 8 - hydroxy - quinoline is also produced during the nitration. Antibacterial and antifungal compositions for topical administration comprise a compound I together with a pharmaceutical carrier.