| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide a stable partner cell for fabricating a rat monoclonal antibody which can be manufactured easily by a simple method, has high merging efficiency with a rat-derived lymphocyte, and has active proliferation capacity despite not being a cancer cell, and to provide a simple fabricating method of the partner cell for fabricating a rat monoclonal antibody, a manufacturing method of a monoclonal antibody using the partner cell for fabricating a rat monoclonal antibody.SOLUTION: A partner cell for fabricating a rat monoclonal antibody according to the present invention is derived from a rat lymphocyte, a TERT gene and a CyclinD1 gene are expressed in the cell, and an expression level of a c-Myc gene is 60% or less with respect to a rat myeloma cell line YB2/0 while an expression level of a p16/p19 gene is 300% or more.</p> |
