摘要 |
1303384 Halogenated o-benzyl-phenols INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES 19 April 1971 [13 Feb 1970] 20902/71 Heading C2C Novel halogenated o-benzyl-phenols of the general formula wherein either R 1 is a hydrogen atom and R 2 is a bromine or fluorine atom or R 1 is a trifluoromethyl group and R 2 is a hydrogen atom, R 3 is a hydrogen or chlorine atom in the 2<SP>1</SP>- or 3<SP>1</SP> - position and R 4 is a chlorine or fluorine atom, are prepared by reaction of a phenol and a benzyl chloride of the respective general formulµ i n the proportion of at least one mole of the phenol per 0À75 mole of the benzyl chloride, in the presence of a zinc chloride catalyst, in a solvent medium and at the reflux temperature thereof. Pharmaceutical compositions having bacteriostatic activity comprise at least one halogenated o-benzyl-phenol of the first general formula above, together with a pharmaceutically acceptable carrier, and may be administered orally or rectally. |