COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET

摘要

The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.

主权项

1. A method for the immunotherapy treatment of a subject with cancer, comprising:
(a) identifying whether the subject is suitable for immunotherapy, the identifying comprising providing a tissue sample from the subject, which contains test cells, wherein the test cells comprise tumor cells and/or tumor-infiltrating leukocytes, and assessing the proportion of test cells in the tissue sample that express B7-H1, the identification being made if <10% of the tumor cells express B7-H1 and/or if an adjusted expression score of the tumor-infiltrating leukocytes is <100; and (b) administering an agent for immunotherapy to the subject,wherein said cancer is renal cell carcinoma.