POLYMERIC BIOMATERIALS DERIVED FROM MONOMERS COMPRISING HYDROXYACIDS AND PHENOL COMPOUNDS AND THEIR MEDICAL USES

摘要

The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.

主权项

1. A biocompatible polymer, comprising a recurring unit of formula;wherein
y1 is 0, 1, 2, 3, or 4: X1 is bromine (Br) or iodine (I); X2 and X3 are independently selected from O, S and NR, where .R is H or lower alkyl; R1 is selected from the group consisting of linear or branched C1-C12 alkylene; A is selected from the group consisting of linear or branched C1-C24 alkylene, R2 is selected, from the group consisting of linear or branched C1-C24 alkylene; n1 and n2 are independently numbers from 0 to 100, and are average values which can be fractional. where the sum of ni and n2 is at least 1; p is zero or 1; and A1 is a linking group selected from: wherein R8 is selected from a bond, C1-C30 alkylene, C2-C30 alkenylene, C2-C30 alkynylene; C1-C30 heteroalkylene, C2-C30 heteroalkenylene, C2-C30 heteroalkynylene, C7-C30 heteroalkylarylene, C8-C30 heteroalkenylarylene, C8-C30 heteroalkynylarylene, C7-C30 alkylarylene, C8-C30 alkenylarylenc. C8-C30 alkynylarylene, and C2-C30 heteroarylene: and R9 and R10 are each independently selected from H, C1-C30 alkyl, C1-C30 heteroalkyl, C2-C30 alkenyl, C2-C30 alkyiryl, C2-C30 hetemalkenyl, and C2-C30 heteroalkynyl: wherein said alkyl and alkylene can be substituted with one or more of hydroxy, alkoxy, halogen, nitro, cyano, CO2R, where R is defined above, phenyl, aryl heteroaryl, cycloalkyl, mercapto, or alkylthio.