| 主权项 |
1. A compound represented by Formula I, its individual enantiomers, individual diastereoisomers, individual tautomers or a pharmaceutically acceptable salt thereof wherein: A is substituted or unsubstituted C6-10 aryl, substituted or unsubstituted heterocycle, substituted or unsubstituted C3-8 cycloalkyl, or substituted or unsubstituted C3-8 cycloalkenyl; R1 is H, halogen, —OR12, C1-8 alkyl, CN, C(O)R13 or NR14R15; R2 is H, halogen, —OR12, C1-8 alkyl, CN, C(O)R13 or, NR14R15; R3 is H, halogen, —OR12, C1-8 alkyl, CN, C(O)R13 or NR14R15; R4 is C1-12 alkyl; R5 is H, halogen, —OR12, C1-8 alkyl, CN, C(O)R13 or NR14R15; R6 is H, halogen, —OR12, C1-8 alkyl, CN, C(O)R13 or NR14R15; R7 is H, halogen, —OR12, C1-8 alkyl, CN, C(O)R13 or NR14R15; R8 is H, halogen, —OR12, C1-8 alkyl, CN, C(O)R13 or NR14R15; R9 is O, S or CH2; R10 is H or C1-8 alkyl; R11 is H, OPO3H2, carboxylic acid, PO3H2, C1-8 alkyl, —S(O)2H, —P(O)MeOH, —P(O)(H)OH or OR16; L1 is O, S, NH or CH2; L2 is CHR14, —CH2—CH2—, O, S, NR15, a direct bond or —C(O)—; a is 0, 1, 2, 3, 4 or 5; b is 0, 1, 2 or 3; R12 is H or C1-8 alkyl; R13 is H, —OC1-8 alkyl, OH, NR14R15 or C1-8 alkyl; R14 is H or C1-8 alkyl; R15 is H or C1-8 alkyl; and R16 is H or C1-8 alkyl. |
