| 摘要 |
<p>A handheld diagnostic system may include a disposable sample holder for receiving and containing a biological sample and an analysis module having a chip-scale microscope. The sample holder may have a transparent portion having test chambers for containing respective portions of a biological sample and that may be inserted into the analysis module. The sample holder may include a plurality of uniformly spaced tick marks. The analysis module may having a housing with an opening configured to receive the transparent portion of the sample holder. The analysis module may include a sensor for detecting the tick marks as the sample holder is inserted into the analysis module. The transparent portion may also include built-in reference features such as reference surfaces, reference markings, and/or reference structures. The chip-scale microscope may include an image sensor for capturing images of the biological sample and the reference features as the transparent portion of the sample holder is inserted into the opening of the analysis module. Each time the sensor detects a tick mark, control circuitry may issue a control signal to the image sensor to capture an image of the biological sample. This type of automated image capture mechanism ensures that images are captured at a uniform spatial distribution even when the sample holder is inserted into the analysis module at variable speed. The analysis module may include a light source for illuminating the sample during image capture operations and optics for gathering light from the sample and focusing the light onto the image sensor. Images of the reference features may be compared with images of the sample and may be used to determine the color, opacity, reflectivity, cell size, and/or cell concentration associated with the sample. The analysis module may transmit sample imaging information to a portable electronic device, which may in turn display corresponding sample analysis information for a user.</p> |
