发明名称 |
MULTISPECIFIC STACKED VARIABLE DOMAIN BINDING PROTEINS |
摘要 |
The present invention concerns multi-specific stacked variable domain binding proteins. |
申请公布号 |
US2015045540(A1) |
申请公布日期 |
2015.02.12 |
申请号 |
US201214128455 |
申请日期 |
2012.06.28 |
申请人 |
SEA LANE BIOTECHNOLOGIES, LLC |
发明人 |
Howowitz Lawrence C.;Bhatt Ramesh R.;Xu Li;Kashyap Arun K.;Wang Sandra M.;Foreman Pamela;Gore Medini;Kobel Phil;Cai Danying |
分类号 |
C07K16/46;C07K16/28;C07K16/22 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
1. A multi-specific Stacked Variable Domain (SVD) binding protein comprising a tandem product of a first heavy chain variable domain sequence conjugated to a second surrogate light chain sequence, associated with a first surrogate light chain sequence conjugated to a second heavy chain variable domain sequence, wherein the tandem product comprises a first binding domain and a second binding domain, wherein each of said first and second binding domains is formed by a surrogate light chain sequence and an antibody variable domain sequence, and wherein each of said first and second binding domains binds specifically to a different binding target. |
地址 |
Mountain View CA US |