Method of generating single VL domain antibodies in transgenic animals

摘要

Abstract The present invention describes methods of generating single VL domain antibodies, including chimeric single chain antibodies that comprise of a variable region of a human immunoglobulin K or X light chain and a non-human constant region. The non-human constant region is devoid of a first constant domain CH1, and the variable region is devoid of a heavy chain variable domain. A Variant Combination for SVLD Ig Locus Structure Alavo SVD Mouse Ig Locus SYD IgO Structure VL regions D regions J regions EA Sy Cy 3LCR LI lhinge CyGene - Fine Structure SC CH2 Ep hinge CH2 Cl 3 M1 M2 Specles Content O- -- -S - aCH3