COMBINATION TREATMENT COMPRISING SULPHATED GLYCOSAMINOGLYCANS FOR INDUCING LABOR

摘要

The present invention refers to the use of certain sulfated glycosaminoglycans for inducing labor. The sulfated glycosaminoglycans have a reduced anticoagulant activity and are used in a combination therapy together with treatment capable of promoting cervical ripening or capable of promoting myometrial contractions of the uterus.

主权项

1. A kit comprising:
a chemically modified heparin or heparan sulfate in combination with an agent capable of promoting cervical ripening or promoting myometrial contractions of the uterus, the chemically modified heparin or heparan sulfate having an antifactor IIa activity of less than 10 IU/mg, an antifactor Xa activity of less than 10 IU/mg, and an average molecular weight (Mw) from about 4.6 to about 6.9 kDa, and comprising: (i) polysaccharide chains essentially free of chemically intact saccharide sequences mediating the anticoagulant effect; and (ii) polysaccharide chains corresponding to molecular weights between 1.2 and 12 kDa with a predominantly occurring disaccharide according to (Formula I), n is an integer from 2 to 20wherein the chemically modified heparin or heparan sulfate comprises non-reducing end unsaturated glucosamines that are presented as signals in the interval of 5.0 to 6.5 ppm in a 1H-NMR spectrum with an intensity (% ratio) of less than 4% in relation to the signal at 5.42 ppm from native heparin.