BISPECIFIC ANTIBODIES

摘要

Provided are bispecific antibodies having a full-size antibody portion with two light chains and two heavy chains, wherein the two heavy chains each is fused to a single-chain variable fragment (scFv) portion. In certain embodiments, the full-size antibody has specificity to EGFR and the scFv has specificity to VEGF.

主权项

1. A bispecific antibody comprising:
(a) a first and a second polypeptides each comprising an immunoglobulin light chain; and (b) a third and a fourth polypeptides each comprising, from the N-terminus to the C-terminus, a variable region, a constant region, and a single-chain variable fragment (scFv), wherein each of the first and second polypeptides, together with each of the variable regions in the third and a fourth polypeptides, form an antigen binding site that specifically recognizes EGFR, and wherein each scFv specifically recognizes VEGF.