发明名称 MORPHOLINE COMPOUNDS AND USES THEREOF
摘要 The present invention relates to compounds of formula;;wherein R1 and R2 are as described herein. Compounds of the invention are useful in the treatment and/or prophylaxis of diseases associated with TAAR modulation.
申请公布号 US2015045359(A1) 申请公布日期 2015.02.12
申请号 US201314328398 申请日期 2013.01.08
申请人 Hoffmann-La Roche Inc. 发明人 Galley Guido;Goergler Annick;Norcross Roger;Pflieger Philippe
分类号 C07D413/10;C07D471/04;C07D487/04;C07D413/14 主分类号 C07D413/10
代理机构 代理人
主权项 1. A compound of formula wherein R1 is a one or two membered heteroaryl group, selected from the group consisting of R2 is hydrogen or halogen; or R1 and R2 may form together with the carbon atoms to with they are attached the following rings R3 is hydrogen, halogen or lower alkyl; n is 1 or 2; R4 is phenyl, optionally substituted by one or two substituents, selected from halogen or cyano, or is pyridinyl, optionally substituted by halogen, or is tetrahydropyran, or is—NH—C(O)-phenyl, optionally substituted by halogen; R5 is hydrogen or halogen; R6-R13 are phenyl, optionally substituted by halogen: R14 is —NH—C(O)-phenyl, substituted by halogen; R15 is hydrogen, lower alkyl substituted by halogen or is halogen; R16 is hydrogen or lower alkoxy; R17 is pyridinyl, optionally substituted by lower alkoxy or lower alkyl substituted by halogen;or a pharmaceutically suitable acid addition salt thereof, all racemic mixtures, all their corresponding enantiomers and/or optical isomers and all tautomeric forms of compounds of formula I.
地址 Little Falls NJ US