| 主权项 |
1. At least one compound selected from compounds of Formula I: stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein:
Q is selected from C and N;W is selected from C and N;X is selected from CH2 and O;Y is selected from NR12, O, and S;Z is selected from O, S, NR13, CO, SO, SO2, and CR13R14;R1, R2, R3, R4, R5, and R6, which may be the same or different, are each selected from hydrogen, halogen, haloalkyl, alkyl, alkenyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, alkynyl, —CN, —NR13R14, —OR13, —COR13, —CO2R13, —CONR13R14, —C(═NR13)NR14R15, —NR13COR14, —NR13CONR14R15, —NR13CO2R14, —SO2R13, —NR13SO2NR14R15, —NR13SO2R14, and —NR13SO2aryl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heteroaryl, aryl, and heterocyclyl are optionally substituted with at least one substituent R16, or (R1 and R2), and/or (R3 and R4), and/or (R5 and R6), together with the ring to which they are attached, form a fused ring selected from heterocyclyl, and heteroaryl rings optionally substituted with at least one substituent R16; provided that R1 is absent when Q is N, and R5 is absent when W is N;R7 is selected from hydrogen, halogen, alkyl, —O-alkyl, and —S-alkyl;R12 is selected from hydrogen and alkyl;R13, R14 and R15, which may be the same or different, are each selected from H, haloalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl; or (R13 and R14), and/or (R14 and R15) together with the atom(s) to which they are attached, each form a ring selected from heterocyclyl, and heteroaryl rings optionally substituted with at least one substituent R16;R16 is selected from halogen, haloalkyl, alkyl, alkenyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, alkynyl, oxo, —CN, —OR′, —NR′R″, —COR′, —CO2R′, —CONR′R″, —C(═NR′)NR″R′″, —NR′COR″, —NR′CONR′R″, —NR′CO2R″, —SO2R′, —SO2aryl, —NR′SO2NR″R′″, NR′SO2R″, and —NR′SO2aryl, wherein R′, R″, and R′″ are independently selected from H, haloalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or (R′ and R″), and/or (R″ and R′″) together with the atoms to which they are attached, form a ring selected from heterocyclyl, and heteroaryl rings. |
