COMPOUNDS FOR THE PREVENTION AND/OR TREATMENT OF OSTEOARTHROSIS

摘要

The present invention relates to new compounds which are inter alia derivable from hops for use in the treatment of (for treating)/prevention or healing of a disease which is associated with an excess transport of hyaluronan across a lipid bilayer, in particular a disease which is associated with or characterized by degeneration and/or a destruction of cartilage (and/or for the prevention of aggrecan loss). Food products comprising these compounds for use in the treatment (for treating) a disease which is associated with an excess transport of hyaluronan across a lipid bilayer, in particular a disease which is associated with or characterized by degeneration and/or a destruction of cartilage, are also envisaged.

主权项

1. A compound of the formulae (I):wherein
R29 is H or CH3 R30 is CH2—CH═C(CH3)2 R31 is H R32 is H, CH3 R33 is H, OH or CH3O R34 is H, OH or CH3O R35 is H, OH or CH3O R36 is H, OH or CH3O R37 is H, OH or CH3Oor a pharmaceutically acceptable salt thereof,and/or (II) wherein R1 is H or CH3O R2 is H R3 is H or CH3 R4 is CH2—CH═C(CH3)2 R5 is H, OH or CH3O R6 is H, OH or CH3O R7 is H, OH or CH3O R8 is H, OH or CH3Oor a pharmaceutically acceptable salt thereofand/or (III)wherein
R1 is H, OH or CH3O R2 is H, OH or CH3O R3 is H, OH or CH3O R4 is H, OH or CH3O R5 is H, OH or CH3O R6 is CH2—CH═C(CH3)2 R7 is H, OH, CH3O or CH3 R8 is H, OH or CH3O R9 is H, OH or CH3Oor a pharmaceutically acceptable salt thereof,for use in the treatment, prevention (prophylaxis) or healing of a disease which is associated with or characterized by an excess transport of hyaluronan across a lipid bilayer.