发明名称 |
POLYPEPTIDE CONSTRUCTS AND USES THEREOF. |
摘要 |
The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen. |
申请公布号 |
MX2014005108(A) |
申请公布日期 |
2015.02.12 |
申请号 |
MX20140005108 |
申请日期 |
2012.10.29 |
申请人 |
TEVA PHARMACEUTICALS AUSTRALIA PTY LTD |
发明人 |
ADAM CLARKE;MATTHEW POLLARD;DAVID S WILSON JR;SARAH L POGUE;GLEN E MIKESELL;TETSUYA TAURA;WOUTER KORVER;ANTHONY G DOYLE;STEPHEN TRAN;JACK TZU CHIAO LIN |
分类号 |
C07K19/00 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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