| 发明名称 |
MODIFIED POLYNUCLEOTIDES ENCODING CASPASE 3 |
| 摘要 |
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. |
| 申请公布号 |
US2015044277(A1) |
申请公布日期 |
2015.02.12 |
| 申请号 |
US201314105210 |
申请日期 |
2013.12.13 |
| 申请人 |
MODERNA THERAPEUTICS, INC. |
发明人 |
Bancel Stephane;Chakraborty Tirtha;de Fougerolles Antonin;Whoriskey Susan;Weiss Ron |
| 分类号 |
A61K48/00;C07K14/485 |
主分类号 |
A61K48/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of producing a protein of interest in a cell, tissue or organism comprising contacting said cell, tissue or organism with a nucleic acid encoding SEQ ID NO: 40219, wherein said nucleic acid comprises a coding region, said coding region having an altered G/C content as compared to the G/C content of the coding region comprising nucleotides 131-964 of SEQ ID NO: 4767. |
| 地址 |
Cambridge MA US |
