RUTHENIUM-BASED METATHESIS CATALYSTS AND PRECURSORS FOR THEIR PREPARATION

摘要

The invention is directed to ruthenium-based metathesis catalysts of the Hoveyda-Grubbs type. The new N-chelating diarylamino-based ruthenium catalysts described herein are stable in solid state and in solution and reveal rapid initiation behavior. Further, the corresponding N-substituted styrene precursor compounds are disclosed. The catalysts are prepared in a cross-metathesis reaction starting from N-substituted styrene precursors. The new Hoveyda-Grubbs type catalysts are suitable to catalyze ring-closing metathesis (RCM), cross metathesis (CM) and ring-opening metathesis polymerization (ROMP). Low catalyst loadings are sufficient to convert a wide range of substrates via metathesis reactions.

主权项

1. Compound of formula (I) for the preparation of ruthenium-based catalysts wherein
a, b, c and d are, independently from each other, selected from hydrogen, straight chain or branched alkyl groups including C1-C10-alkoxy, C1-C10-alkylthio, C1-C10-alkylamino, optionally substituted C6-C14-aryl, optionally substituted C6-C14-aryloxy, optionally substituted C6-C14-heteroaryl or electron-withdrawing groups (EWG);R1 is selected from straight chain or branched C1-C10-alkyl, C1-C10-alkylcarbonyl, C5-C6-cycloalkyl or C6-C14-aryl groups;R2 is selected from hydrogen, straight chain or branched alkyl groups including C1-C10-alkyl, C1-C10-alkoxy, C1-C10-alkylthio, C1-C10-silyloxy, C1-C10-alkylamino, C6-C14-aryl, C6-C14-aryloxy, C6-C14-heterocyclic or electron-withdrawing groups (EWG);R3 is selected from hydrogen, straight chain or branched C1-C10-alkyl groups;and wherein R1 and R2 optionally may form a ring.