发明名称 |
SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF |
摘要 |
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a [(1-Piperazinyl)-4-pyridinylmethyl]-Naphtho[1,2-b]furan structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases. |
申请公布号 |
US2015045357(A1) |
申请公布日期 |
2015.02.12 |
申请号 |
US201314386230 |
申请日期 |
2013.03.29 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
Nikolovska-Coleska Zaneta;Bajwa Naval;Liao Chenzhong;Miao Lei |
分类号 |
C07D405/06;A61K31/5377;A61K45/06;A61K31/496 |
主分类号 |
C07D405/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Ann Arbor MI US |