MICROFLUIDIC DEVICE WITH HYDROPHOBIC SURFACE MODIFICATION LAYER AND MANUFACTURING METHOD THEREOF

摘要

A microfluidic device includes a support body having a first surface and a second surface opposite to one another. The first surface is hydrophilic. A surface modification layer extends over the first surface of the support body. At least one opening is formed to extend through the surface modification layer and expose a portion of the first surface. The surface modification layer is hydrophobic. In particular, the surface modification layer is made of a photodefinible material chosen from among: an epoxy resin, a polyamide, and a photocurable siloxane-based polymer. The openings are functionalized using probe molecules designed to bind with specific target molecules to be detected.

主权项

1. A microfluidic device, comprising:
a support body having a first surface and a second surface opposite to one another, wherein the first surface is hydrophilic; a hydrophobic surface modification layer extending over the first surface of the support body, wherein the surface modification layer has at least one opening extending completely through the surface modification layer, thus exposing a portion of the first surface, and wherein the surface modification layer is made of a photodefinible material selected from the group consisting of: an epoxy resin, a polyamide, and a photocurable siloxane-based polymer; and at least one sensing region housed in each opening comprising one or more receptors which are configured to bond with respective one or more binding mates.