发明名称 |
MATERIALS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS AND FOR INDUCTION OF ION SECRETION |
摘要 |
<p>The present invention provides materials and methods for inducing ion secretion and/or for treating cystic fibrosis. In one embodiment, the composition comprises glucose and/or a non-metabolizable glucose analog and/or non-structural protein (NSP4), a NSP4 peptide, or a NSP4 toxoid as the active ingredient, formulated with pharmaceutically-acceptable carriers. In a preferred embodiment, the composition is in a form of an aerosol preparation for intranasal and/or pulmonary administration, and is used to stimulate chloride and fluid secretion in nasal, tracheal and/or bronchial epithelium.</p> |
申请公布号 |
EP2833891(A1) |
申请公布日期 |
2015.02.11 |
申请号 |
EP20130772867 |
申请日期 |
2013.03.15 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
VIDYASAGAR, SADASIVAN;OKUNIEFF, PAUL;PRABHAKARAN, SREEKALA;ZHANG, LURONG |
分类号 |
A61K31/7034;A61K9/12;A61K9/72;A61K31/70;A61K38/16;A61K38/17 |
主分类号 |
A61K31/7034 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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