The present invention is directed to a novel method for preparing a synthetic intermediate for treprostinil via a stereoselective alkyne addition reaction. Also described are methods of preparing treprostinil comprising the alkyne addition reaction described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.
申请公布号
EP2576492(A4)
申请公布日期
2015.02.11
申请号
EP20110790417
申请日期
2011.06.02
申请人
UNITED THERAPEUTICS CORPORATION
发明人
BATRA, HITESH;PENMASTA, RAJU;SHARMA, VIJAY;TULADHAR, SUDERSAN M.;WALSH, DAVID A.