METHODS AND COMPOSITIONS FOR DENGUE VIRUS EPITOPES
摘要
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein domain I and domain II hinge region from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
申请公布号
EP2834265(A1)
申请公布日期
2015.02.11
申请号
EP20130772201
申请日期
2013.03.15
申请人
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;VANDERBILT UNIVERSITY
发明人
DE SILVA, ARAVINDA M.;DE ALWIS, A. RUKLANTHI;WAHALA, WAHALA M.P.B.;BARIC, RALPH S.;MESSER, WILLIAM B.;CROWE, JR., JAMES E.;SMITH, SCOTT A.
