| 主权项 |
1. A compound having structural Formula I or a pharmaceutically acceptable salt thereof wherein: R1 is —H, halo, —OH, or —OC1-3alkyl; m is an integer selected from zero (R3b is absent) and 1 (R3b is present); n is an integer selected from 1 or 2; R2 is independently selected at each occurrence from —H, ═O (oxo), —OH, —C1-3alkyl or —OC1-3alkyl, provided that when n is 2, then at least one R2 is —H; R3a is —H, C1-3alkyl or cyclopropyl, R3b is —H or —C1-3alkyl; R4 is —H or ═O; R5 is (a) —H, (b) halo, (c) —C1-3alkyl, or (d)-C3-6cycloalkyl; R6 is —H or —C1-3alkyl; R7a is —H or —C1-3alkyl optionally substituted with —OH, —OCH3 or 1 to 3 of —F; R7b is —H or —C1-3alkyl; R8 is —H, halo or —C1-3alkyl; R9 is —H, —F, —OH, —OC1-3alkyl, —CH2OH, —NH—R13 or R10 is —H, halo, —CN, —C3-4cycloalkyl, or —C1-3alkyl optionally substituted with 1 to 3 of —F; or R9 is —O— and is joined together with R10 to represent —CH2—CH2—O—; R11 is —H, —CH2OH, —CH2OCH3, or —C1-3alkyl optionally substituted with 1 to 3 of —F; R12 is —H, —CH2OH, —CH2OCH3, or —C1-3alkyl optionally substituted with 1 to 3 of —F; or R11 and R12 are joined together to represent —CH2—CH2—, —CH2—N(CH3)—CH2— or —CH2OCH2—; R13 is —H, —(CH2)0-2—C3-6cycloalkyl, —(CH2)1-2—OC3-6cycloalkyl, —(CH2)1-2—OC1-3alkyl, —(CH2)1-2—CN, —C(O)OC1-3alkyl, —SO2CH3 or —C1-3alkyl optionally substituted with one to three of —F; and the dashed bond (“- - -”) represents a single, or double bond, provided that
(A) when n is 2, then the dashed bond is a single bond and m is 1; and(B) when n is 1 and
m is 1,then the dashed bond is a single bond; and(C) when n is 1, m is zero and R2 is not ═O, then the dashed bond is
a double bond. |
