Inhibitors of syk and JAK protein kinases

摘要

The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

主权项

1. A method for inhibiting syk or JAK kinase or a signal transduction pathway mediated at least in part by syk kinase activity comprising the step of contacting a cell with a compound
having the formula: or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein each X and Y is independently selected from the group consisting of: CH2 and O; each E1 is independently selected from the group consisting of C1-8alkyl, heteroaryl, heterocyclyl, halo, C1-8haloalkyl, C1-8alkoxy, cyano, C1-8acyl, aminoC1-8alkyl, aminosulfonyl, C1-8alkylsulfonyl and acylamino; and R5 is heteroaryl; and the subscript n is 0, 1, 2, 3 or 4.