Chemical compounds

摘要

The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I):;
and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.

主权项

1. A compound according to formula (I)wherein
R1 is selected from (C1-C4)alkyl, (C3-C4)cycloalkyl, NH2, and NH(C1-C4)alkyl and R2 is H; or R1 and R2 together are —CH2—CH2— or —N(CH3)—CH2—; R3 is selected from H, F, CHF2, OCH3 and CN; R4 is selected from H, F, Cl, OH, OCH3 and CN; and R5 is selected from (C2-C4)alkyl, (C3-C5)cycloalkyl and methyl-substituted (C3-C5)cycloalkyl,or a pharmaceutically acceptable salt thereof.