Methods of using small compounds to enhance myeloid derived suppressor cell function for treating autoimmune diseases

摘要

Methods for enhancing the suppressive function of myeloid derived suppressor cells (MDSCs) for the treatment of autoimmune diseases using small compounds are disclosed. In certain aspects, the small compounds are glatiramer acetate and mitogen activated protein (MAP) kinase inhibitors. In other aspects, these methods include the administration of exogenous MDSCs or the use of endogenous MDSCs mobilized using stem cell mobilizers. In yet other aspects, compositions containing MDSCs and small compounds of the invention are provided.

主权项

1. A method for suppressing a T-cell-mediated pro-inflammatory immune response in a mammal, which comprises administering to a mammal in need of such treatment an effective amount for suppressing the T-cell-mediated immune response of:
(i) a myeloid derived suppressor cell (MDSC); and (ii) glatiramer acetate (GA); wherein the MDSC is an immunosuppressive cell capable of suppressing antigen-specific T cell proliferation and inducing Foxp3+ T regulatory cells.