| 发明名称 | Compositions for improving migration potential of stem cells | ||
| 摘要 | The present invention relates to a composition for improving the migration potential of a stem cell, a method for evaluating the migration potential of a stem cell and a method for screening an adjuvant of cell therapy improving the migration potential of a stem cell. The present invention may be effectively used for enhancing the efficacy of neurological disease-treatment by inducing therapeutic stem cells to migrate efficiently to the lesion site. | ||
| 申请公布号 | US8951511(B2) | 申请公布日期 | 2015.02.10 |
| 申请号 | US201013502806 | 申请日期 | 2010.10.19 |
| 申请人 | Corestem Co., Ltd. | 发明人 | Koh Seong Ho;Kim Seung Hyun;Cho Goang Won;Noh Min Young;Kim Kyung Suk |
| 分类号 | A01N63/00;A61K48/00;C12N15/00;C12N15/86;C12N5/00;C12N5/02;C12N15/88;A61K35/28;C07K14/47;A61K38/00 | 主分类号 | A01N63/00 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Clark & Elbing LLP |
| 主权项 | 1. A method for improving the migration potential of a mesenchymal stem cell, comprising introducing into the mesenchymal stem cell a gene delivery system that expresses a nucleotide sequence encoding β-PIX having the amino acid sequence of SEQ ID NO:2 in the mesenchymal stem cell, wherein expression of said nucleotide sequence improves the migration potential of said mesenchymal stem cell when compared to a mesenchymal stem cell that does not express said nucleotide sequence. | ||
| 地址 | Chungcheongbuk-do KR | ||