Multifunctional radical quenchers and their uses

摘要

The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof: compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

主权项

1. A compound of formula: or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, or —CO(C1-C6 alkyl); R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or C1-C6 alkoxy, each optionally substituted with one to four substituents selected from halogen, cyano, nitro, C1-C6 alkyl, halo(C1-C6 alkyl), —OR6, —NR62, —CO2R6, and —CONR62; where each R6 independently is hydrogen or C1-C6 alkyl; R2 is C7-C20 alkyl, C7-C20 alkenyl, or C7-C20 alkynyl, each optionally substituted with one to four substituents selected from halogen, cyano, nitro, C1-C6 alkyl, halo(C1-C6 alkyl), —OR7, —NR72, —CO2R7, and —CON(R7)2; where each R7 independently is hydrogen, C1-C6 alkyl, or halo(C1-C6 alkyl); X is CR3 or N; where R3 is hydrogen, C1-C6 alkyl, halo(C1-C6 alkyl), —OR7, —NR72, —CO2R7, or —CON(R7)2; Y is CR4; where R4 is hydrogen, C1-C6 alkyl, halo(C1-C6 alkyl), —OR7, —NR72, —CO2R7, —CON(R7)2, aryl, heteroaryl or heterocyclyl ring, which is optionally substituted with one to four substituents selected from halogen, cyano, nitro, C1-C6 alkyl, halo(C1-C6 alkyl), —OR7, —NR72, —CO2R7, and —CON(R7)2; and Z is CR5 or N; where R5 is hydrogen, C1-C6 alkyl, halo(C1-C6 alkyl), —OR7, —NR72, —CO2R7, or —CON(R7)2, or
where R4 and R5 together with the atoms to which they are attached form 5-7 member heteroaryl or heterocyclyl ring, which is optionally substituted with one to four substituents selected from halogen, cyano, nitro, C1-C6 alkyl, halo(C1-C6 alkyl), —OR7, —NR72, —CO2R7, and —CON(R7)2, provided that at least one of X and Z is N.