发明名称 |
Polyoxyethylene derivative having plural hydroxyl groups at terminal end thereof |
摘要 |
A polyoxyethylene derivative represented by the formula (1):;
wherein a whole molecular weight of the polyoxyethylene derivative is 500 to 160,000; n is 5 to 3650; L1, L2, and L3 each independently represent an alkylene group, a phenylene group, an ester bond, an amide bond, an ether bond, a urethane bond, a carbonate bond, a secondary amino group, or a combination thereof; X represents a functional group capable of reacting with a bio-related substance; Y represents a hydrophilic group having plural hydroxyl groups made from a residual group of xylitol or volemitol or a residual group of polyglycerin of trimer to 31-mer; Z represents a residual group of a compound having 2 to 5 active hydrogen atoms; b and c are as follows: 1≦b≦4, 1≦c≦4, and 2≦b+c≦5; and d and e each independently are 0 or 1. |
申请公布号 |
US8952125(B2) |
申请公布日期 |
2015.02.10 |
申请号 |
US201213435556 |
申请日期 |
2012.03.30 |
申请人 |
NOF Corporation |
发明人 |
Yoshioka Hiroki;Matani Takashi;Yamamoto Yuji |
分类号 |
C08G65/04;C08G65/34;A61K47/48;C08G65/26;C08G65/333;C08G65/00 |
主分类号 |
C08G65/04 |
代理机构 |
Sughrue Mion, PLLC |
代理人 |
Sughrue Mion, PLLC |
主权项 |
1. A polyoxyethylene derivative represented by the formula (2): wherein a whole molecular weight of the polyoxyethylene derivative is 500 to 160,000; n is 5 to 3650; L1, L2, and L3 each independently represent an alkylene group, a phenylene group, an ester bond, an amide bond, an ether bond, a urethane bond, a carbonate bond, a secondary amino group, or a combination thereof; X represents a functional group capable of reacting with a bio-related substance; Z represents a residual group of a compound having 2 to 5 active hydrogen atoms; a is 1 or 2; b and c are as follows: 1≦b≦4, 1≦c≦4, and 2 ≦b+c≦5; and d and e are 0 or 1. |
地址 |
Tokyo JP |