Compounds for the prevention and treatment of cardiovascular disease

摘要

Disclosed are novel compounds that are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for the treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis. Also disclosed are pharmaceutical compositions comprising the novel compounds. Formula (I);

主权项

1. A compound of Formula I:or a stereoisomer, tautomer, pharmaceutically acceptable salt, or hydrate thereof, wherein
Y is carbon; W is nitrogen; Ra6 is selected from fluoride, hydrogen, C1-C3 alkoxy, cyclopropyloxy, SO2R3, SOR3, and SR3, wherein if Y is nitrogen then Ra6 is absent; Ra7 is selected from hydrogen, fluoride, SO2R3, SOR3, and SR3; Ra8 is selected from hydrogen, C1-C3 alkoxy, cyclopropyloxy, chloride, and bromide; AR is n is selected from 1, 2, or 3; D is selected from O, NH, NR1, S, or C; Rb3 and Rb5 are independently selected from hydrogen and C1-C3 alkyl; Rc3 and Rc5 are independently selected from hydrogen, C1-C3 alkyl, and cyclopropyl; Rc4 is selected from F, Cl, Br, I, CF3, C1-C6 alkyl, C3-C6 cycloalkyl, NHC(O)R4, NHSO2R4, C(O)OR4, and R1, R′1, R2 and R′2 are independently selected from hydrogen, fluoride, C1-C3 alkyl, and cyclopropyl, wherein R1 and R2 and/or R′1 and R′2 may be connected to form a 3-6 membered ring; R3 is selected from C1-C3 alkyl and cyclopropyl; and R4 is selected from hydrogen, C1-C4 alkyl, C3-C5 cycloalkyl, and aryl, provided that if Ra7 or Ra6 is fluoride, then Rc4 is not bromide.