| 发明名称 | Method for modulating activity of T lymphocytes | ||
| 摘要 | The invention relates to methods and compositions which modulate T lymphocyte activity. It has been found that two, T lymphocyte receptors, especially TCR and CD8, are present at a distance from each other on T lymphocyte surfaces. Via use of modulators which change the distance between these receptors, the activity of the T lymphocyte is modulated. | ||
| 申请公布号 | US8951747(B2) | 申请公布日期 | 2015.02.10 |
| 申请号 | US201213429873 | 申请日期 | 2012.03.26 |
| 申请人 | Ludwig Institute for Cancer Research | 发明人 | Demotte Nathalie;Van Der Bruggen Pierre;Boon-Falleur Thierry |
| 分类号 | G01N33/00;C12N5/00;C12N5/07;A61K31/7016;A61K31/4745;A61K45/06;C07K14/725;C07K14/705;G01N33/50;C12N5/0783;C07K16/28;A61K39/00 | 主分类号 | G01N33/00 |
| 代理机构 | Abelman, Frayne & Schwab | 代理人 | Abelman, Frayne & Schwab |
| 主权项 | 1. A method for increasing activity of a T lymphocyte consisting of contacting said T lymphocyte with a composition consisting of a galectin-3 ligand and a carrier, in an amount sufficient to reduce distance between a T cell receptor and a T lymphocyte co-receptor to a point sufficient to increase activity of said T lymphocyte, said contacting occurring in vitro. | ||
| 地址 | New York NY US | ||