Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers

摘要

The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express 158P1D7 and variants thereof.

主权项

1. A method for detection, the method comprising:
contacting a bladder test sample with a binding partner and measuring specific binding of the binding partner to a protein in the bladder test sample, thereby determining an expression level of the protein in the bladder test sample, wherein the binding partner specifically binds to a protein consisting of the amino acid sequence of SEQ ID NO: 3, wherein the binding partner specifically binds to a region of the protein within amino acid residues 25-45 or 274-285 of SEQ ID NO: 3.