Devices and methods for photodynamically modulating neural function in a human

摘要

Devices and methods for therapeutic photodynamic modulation of neural function in a human. One embodiment of a method in accordance with the technology includes administering a photosensitizer to a human, wherein the photosensitizer preferentially accumulates at nerves proximate a blood vessel compared to non-neural tissue of the blood vessel. The method can further include irradiating the photosensitizer using a radiation emitter positioned within the human, wherein the radiation has a wavelength that causes the photosensitizer to react and alter at least a portion of the nerves thereby providing a therapeutic reduction in sympathetic neural activity. Several embodiments of the technology are useful for disrupting renal nerves, such as renal denervation, for treating hypertension, diabetes, congestive heart failure, and other indications.

主权项

1. A method for therapeutic neural denervation in a human patient, the method comprising:
administering a photosensitizer to the patient, wherein
the photosensitizer comprises oxytetracycline administered at a dosage of 0.5-600mg/kg body weight, andwherein the photosensitizer selectively accumulates at nerves proximate a blood vessel compared to non-neural tissue of the blood vessel; irradiating the photosensitizer at the nerves proximate the blood vessel via radiation from a radiation emitter positioned within the human, wherein
the oxytetracycline is administered 0.5-24 hours before irradiating the photosensitizer, and the radiation is pulsed at of 2 ps- 50 ps to a dosage of 0.5-500 J/cm2,and wherein the radiation has a wavelength that causes the photosensitizer to react and alter at least a portion of the nerves thereby providing a therapeutic reduction in sympathetic neural activity.