Aminoheteroaryl compounds and preparation method and use thereof

摘要

The present invention refers to aminoheteroaryl compounds of the following formula (I) as well as the preparation method and use thereof, wherein R1 and R3 are defined in the Description in details. The aminoheteroaryl compounds of the present invention are inhibitors of hepatocyte growth factor receptor (c-Met), have favorable inhibitory effect against c-Met and inhibitory effect against the proliferation of cancer cells, such that they may be used as therapeutic agents for the treatment of tumors and related diseases.;

主权项

1. A compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof,wherein:
R1 is selected from H, C1-C6alkyl, C1-C6alkyl substituted by 1-3 halogen, C3-C8cycloalkyl, C3-C8cycloalkyl substituted by 1-3 halogen, —CONR′R″, aryl, heteroaryl or nitrogen-containing saturated heterocyclyl; R2 is selected from —OR3, —SR3 or —NR3, wherein R3 is H, C1-C6alkyl, C1-C6alkyl substituted by 1-3 halogen, —(CR′R″)0-6-aryl, —(CR′R″)0-6-heteroaryl or —(CR′R″)0-6— nitrogen-containing saturated heterocyclyl; and wherein: said aryl, heteroaryl and nitrogen-containing saturated heterocyclyl is unsubstituted or substituted by halogen, C1-C6alkyl, C1-C6alkyl substituted by aryl, C1-C6alkoxy, C3-C8cycloalkyl, —NR′R″, —COR′″, —COOR′″, —SOOR′″ or —OH; said R′ and R″ are each independently H, C1-C4alkyl or C1-C4alkyl substituted by 1-3 halogen; and said R′″ is selected from the following groups: H, C1-C4alkyl, C1-C4alkyl substituted by 1-3 halogen, aryl that is unsubstituted or substituted by halogen, C1-C4alkyl, C1-C4alkoxy, —CN, —NH2 or —OH and heteroaryl that is unsubstituted or substituted by—halogen, C1-C4alkyl, C1-C4alkoxy, —CN, —NH2 or —OH.