Assessing susceptibility to cardiac intervention, susceptibility to therapy for heart failure, risk of mortality or further cardiovascular events, and risk of subsequent pulmonary embolism in relevant patients based on determinations of GDF-15, natriuretic peptide, cardiac troponin or combinations thereof

摘要

The present invention relates to a method of identifying a subject being susceptible to a cardiac intervention based on the determination of GDF-15 in a sample of a subject in need of a cardiac intervention. Moreover, the present invention pertains to a method for predicting the risk of mortality or a further acute cardiovascular event for a subject suffering from a cardiovascular complication based on the determination of GDF-15 and a natriuretic peptide and/or a cardiac troponin in a sample the said subject. Also encompassed by the present invention are devices and kits for carrying out the aforementioned methods.

主权项

1. A method for identifying a subject as suitably treated by a cardiac intervention, the method comprising:
contacting a portion of a sample from the subject with an antibody having specific binding affinity for growth differentiation factor 15 (GDF-15), thereby forming a complex between the antibody and GDF-15, the antibody having a detectable label; separating the complex formed in said step of contacting from antibody not comprising the complex; quantifying a signal from the detectable label of the antibody comprising the complex formed in said step of contacting, the signal being proportional to an amount of GDF-15 in the sample, whereby an amount of GDF-15 in the sample is calculated; comparing the amount of GDF-15 calculated in said step of quantifying to a reference amount for GDF-15, wherein the reference amount for GDF-15 is 1200 pg/ml; and identifying the subject as suitably treated by a cardiac intervention if the amount of GDF-15 calculated in said step of quantifying is larger than the reference threshold amount for GDF-15.