| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry and specifically to nitroimidazooxazine derivatives of general formula I, where n equals 1, V and W independently denote H or CH, and one of X and Y is H and the other is one of the formulaeand, where formula IIa includes a single ring labelled at position 3 and position 4 and containing Ras a substitute, and formula IIb includes a first ring labelled at position 3 and position 4 and containing as substitutes both Rand a terminal ring, labelled at position 4 and containing Ras a substitute, where the single ring of formula IIa and the first ring and the terminal ring of formula IIb include C, CH, or N at each ring position, where the single ring of formula IIa and the first ring and the terminal ring of formula IIb independently contain no more than two nitrogen atoms; Z in formulae IIa and IIb is CHor a direct bond, Ris independently any one or two of H, F, C1, CF, OCFor OCHPh, and Ris H. The invention also relates to a pharmaceutical composition based on the compound of formula I, a method of preventing and treating a microbial infection based on use of the compound of formula, and specific nitroimidazooxazine derivatives.EFFECT: obtaining novel compounds with useful biological activity.7 cl, 21 dwg, 3 tbl |
