In situ film-forming bioactive solutions of absorbable multiblock copolymers

摘要

An in situ film-forming methyl acetate-based solution of at least one absorbable, segmented block copolymer with amorphous and semi-crystalline segments contains at least one bioactive agent which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane. The solution can be applied (e.g., sprayed or swabbed) onto animal and human skin or accessible body cavities to prevent or treat one or more disorders preventable or treatable by the bioactive agent therein.

主权项

1. An in situ film-forming solution comprising
at least one absorbable, segmented block copolymer with amorphous and semi-crystalline segments wherein the copolymer is a polyaxial coplolyester made from trimethylene carbonate and at least one cyclic monomer selected from the group consisting of p-dioxanone, 1,5-dioxapan-2-one, glycolide, l-lactide, ε-caprolactone, and a morpholinedione; a solvent comprising methyl acetate; and at least one bioactive agent selected from the group consisting of chlorhexidine and silver nitrate antimicrobial agents, anesthetic agents, antiviral agents, anti-inflammatory agents, hemostatic agents, and antineoplastic agents.