发明名称 |
Substance specific to human PD-1 |
摘要 |
The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy. |
申请公布号 |
US8951518(B2) |
申请公布日期 |
2015.02.10 |
申请号 |
US201213548807 |
申请日期 |
2012.07.13 |
申请人 |
Ono Pharmaceutical Co., Ltd. |
发明人 |
Honjo Tasuku;Shibayama Shiro;Takeda Kazuhiko;Matsuo Masayoshi;Yoshida Takao;Miyamoto Masakazu |
分类号 |
A61K39/395;C07K16/28;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
Sughrue Mion, PLLC |
代理人 |
Sughrue Mion, PLLC |
主权项 |
1. A preventive and/or therapeutic method for insulin dependent diabetes mellitus, comprising administering an effective amount of a bispecific antibody to an insulin dependent diabetes mellitus patient, wherein the bispecific antibody comprises the following parts;
(a) VH region of anti-human PD-1 antibody; (b) VL region of anti-human CD3 antibody; (c) VH region of said anti-human CD3 antibody; and (d) VL region of said anti-human PD-1 antibody, and wherein each of said part is linked by peptide linkers, so that said part (a) can bind to human PD-1 together with said part (d) and said part (c) can bind to human CD3 together with said part (b). |
地址 |
Osaka JP |