Methods for treating bone disorders by characterizing and restoring mammalian bacterial microbiota

摘要

The present invention relates to characterizing changes in mammalian gastrointestinal microbiota associated with antibiotic treatment and various disease conditions (such as obesity, metabolic syndrome, insulin-deficiency or insulin-resistance related disorders, glucose intolerance, diabetes, non-alcoholic fatty liver, abnormal lipid metabolism, short stature, osteoporosis, and other disorders of bone formation and mineralization, etc.) and related diagnostic and therapeutic methods. Therapeutic methods of the invention involve the use of probiotics, prebiotics, or narrow spectrum antibiotics/anti-bacterial agents that are capable of restoring healthy mammalian bacterial gastrointestinal microbiota.

主权项

1. A method of treating a disease in a mammal in need thereof, wherein the disease is selected from the group consisting of osteoporosis and other disorders of bone formation and mineralization, said method comprising administering to the mammal a therapeutically effective amount of a probiotic composition comprising one or more conditionally lethal bacterial strains, wherein the composition (i) stimulates the growth or activity of one or more bacterial taxa which are under-represented in microbiota of the mammal as compared to a healthy control or (ii) inhibits the growth or activity of one or more bacterial taxa which are over-represented in microbiota of the mammal as compared to a healthy control.