T-cell receptor and nucleic acid encoding the receptor

摘要

A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence, the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4143-151-specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 2 of Sequence Listing.

主权项

1. A method of treating cancer, which comprises:
administering a carcinostatic agent to a patient in need thereof comprising, as an active ingredient, a cell transduced or transformed with a nucleic acid (A) and a nucleic acid (B), and expressing in said cell the nucleic acid (A) and the nucleic acid (B), wherein the nucleic acid (A) encodes a polypeptide comprising the amino acid sequence of SEQ ID NO: 5, and wherein a nucleic acid (B) encodes a polypeptide comprising the amino acid sequence of SEQ ID NO: 7, wherein expression of the nucleic acids (A) and (B) results in production of polypeptides that form a receptor that specifically binds an HLA-A24-restricted, MAGE-A4143-151 complex, wherein the transduced or transformed cell is a T cell, and wherein the cancer expresses HLA-A24-restricted, MAGE-A4143-151 antigen.