Phosphorus containing compounds as protein kinase inhibitors

摘要

The present invention relates to compounds represented by formula (I), which can modulate the activity of protein kinases. The invention also relates to a composition containing a compound of formula (I), and a method for synthesizing and using such compound for preventing or treating ALK or cMet mediated disorders or conditions.;

主权项

1. A compound of formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof,wherein Y is N, or CR6;
L1 and L2 are independently selected from the group consisting of a bond, —O—, —N(H)—, —S—, —OR6—, —SR6—, —NR6—, —R6NR7—, —R6OR7—C(O)N(R6)—, —NR6C(O)—, —C(O)NR6—, —R6S(O)2—, —R6S(O)rR7—, —R6S(O)2NR7—, —NR6S(O)2R7—, —C(O)R6—, —OC(O)NR6—, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted C6-12 aryl, unsubstituted or substituted C3-12 carbocyclic, unsubstituted or substituted 3- to 12-membered heterocyclyl, and unsubstituted or substituted 3- to 12-membered heteroaryl; where L1 and L2 can be attached to in any position of the group; and where r is an integer from 0-2; W1 is selected from the group consisting of unsubstituted or substituted C3-12 carbocyclic, unsubstituted or substituted 3- to 12-membered heterocyclyl, unsubstituted or substituted C6-12 aryl, unsubstituted or substituted heteroaryl, when C6-12 aryl or heteroaryl is substituted with only two substituents, the two substituents are not in para positions; W2 is selected from the group consisting of unsubstituted or substituted C6-12 aryl, and unsubstituted or substituted 3- to 12-membered heteroaryl; R1 is selected from the group consisting of hydrogen, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, —SR6, —S(O)R6, —S(O)2R6, —S(O)2NR6R7, —NO2, —NR6R7, —CN, —C(O)R6, —OC(O)R6, —OR6, —CONR6R7, —NR6C(O)R7, unsubstituted or substituted C3-12 cycloalkyl, unsubstituted or substituted C6-12 aryl, unsubstituted or substituted 3- to 12-membered heterocyclic, and unsubstituted or substituted 5- to 12-membered heteroaryl; R2 and R3 are independently selected from the group consisting of hydrogen, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted carbocyclic, unsubstituted or substituted C6-12 aryl, unsubstituted or substituted 3-12 membered heterocyclic, and unsubstituted or substituted 5-12 membered heteroaryl; or R2 and R3 may combine with an atom or atoms to which they are attached to form unsubstituted or substituted C3-12 cycloalkyl, unsubstituted or substituted 3- to 12-membered heterocyclic, unsubstituted or substituted C6-12 aryl, or unsubstituted or substituted 5- to 12-membered heteroaryl; and R4 and R5 are independently selected from the group consisting —OR6, —NR6R7, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, and unsubstituted or substituted C3-C10 cycloalkyl; or R4 and R5 together with atom(s) to which they are attached form an unsubstituted or substituted 3- to 12-membered ring;
wherein R6 and R7 are independently selected from the group consisting of hydrogen, halogen, unsubstituted or substituted C1-12 alkyl, unsubstituted or substituted C2-12 alkenyl, unsubstituted or substituted C2-12 alkynyl, unsubstituted or substituted C3-12 cycloalkyl, unsubstituted or substituted C6-12 aryl, unsubstituted or substituted 3-12 membered heterocyclic, and unsubstituted or substituted 5-12 membered heteroaryl.