| 发明名称 | Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1 | ||
| 摘要 | The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Paraoxonase 1(PON1), in particular, by targeting natural antisense polynucleotides of Paraoxonase 1(PON1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PON1. | ||
| 申请公布号 | US8951981(B2) | 申请公布日期 | 2015.02.10 |
| 申请号 | US201013377884 | 申请日期 | 2010.06.16 |
| 申请人 | CuRNA, Inc. | 发明人 | Collard Joseph;Khorkova Sherman Olga |
| 分类号 | A61K48/00;C07H21/02;C07H21/04 | 主分类号 | A61K48/00 |
| 代理机构 | CuRNA, Inc. | 代理人 | CuRNA, Inc. ;Browder Monte R. |
| 主权项 | 1. A method of upregulating a function of and/or the expression of a Paraoxonase 1 (PON1) polynucleotide having SEQ ID NO: 1 in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one single stranded antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide has at least 80% sequence identity to a reverse complement of a polynucleotide comprising 12 to 30 nucleotides within nucleotides 1 to 534 of SEQ ID NO: 2; thereby upregulating a function of and/or the expression of the Paraoxonase 1 (PON1) polynucleotide in patient cells or tissues in vivo or in vitro. | ||
| 地址 | Miami FL US | ||