Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery

摘要

The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.

主权项

1. An insertable medical device to deliver a bioactive agent to blood vessels of a subject, the device comprising:
an expandable elastic portion, a flexible biostable hydrogel matrix selected from the group consisting of poly(acrylamide), poly(methacrylamide), poly(vinylpyrrolidone), poly(acrylic acid), poly(ethylene glycol), poly(vinyl alcohol), poly(2-hydroxyethyl methacrylate), methyl vinyl ether/maleic anhydride copolymers, and vinyl pyrrolidone/(meth)acrylamide copolymers, wherein the flexible biostable hydrogel matrix forms a non-contiguous coating on the outer surface of the expandable elastic portion, and microparticulates having an average greatest dimension in the range of 0.1 μm to 10 μm associated with an outer surface of the flexible biostable hydrogel matrix when the flexible biostable hydrogel matrix is in a dehydrated state, wherein the microparticulates comprise a water-insoluble bioactive agent, and wherein a portion greater than 50% of the microparticulates associated with the outer surface of the flexible biostable hydrogel matrix disassociates from the flexible biostable hydrogel matrix upon hydration of the flexible biostable hydrogel matrix and expansion of the elastic portion to contact the hydrated flexible biostable hydrogel matrix and microparticulates with the blood vessels of the subject.