发明名称 |
PREPARATION OF EXTREMELY SMALL AND UNIFORM-SIZED, IRON OXIDE-BASED PARAMAGNETIC OR PSEUDO-PARAMAGNETIC NANOPARTICLES AND MRI T1 CONTRAST AGENTS USING SAME |
摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing paramagnetic iron oxide nanoparticles. The disclosed method includes reacting an iron complex having iron as a central atom and a carboxylate group having 10 to 22 carbon atoms which is bonded to the central atom in a ligand form; a C10-C22 fatty acid and a C10-C22 aliphatic alcohol or C10-C22 aliphatic amine to obtain iron oxide nanoparticles. The iron oxide nanoparticles are obtained by raising the temperature from room temperature to 200 to 250°C with at a rate of 5°C/min or higher, and conducting the reaction at 200 to 250°C for 5 to 60 min.EFFECT: invention enables to obtain iron oxide nanoparticles having a size of 4nm or less, which can be used as a MRI T1 contrast agent.7 cl, 1 tbl, 25 dwg, 31 ex |
申请公布号 |
RU2540472(C2) |
申请公布日期 |
2015.02.10 |
申请号 |
RU20130109406 |
申请日期 |
2011.08.05 |
申请人 |
KHANVKHA KEMIKAL KORPOREJSHN |
发明人 |
KHIEON TAEG KHVAN;KIM BIUNG KHIO;LI NO KHIUN;KIM EUNG GIU;DZEON BONG SIK;KVON EUN BIUL;PARK DZU JOUNG;MIEONG VAN DZAE |
分类号 |
A61K49/08;A61K9/16;A61K47/02;A61K47/48;A61K49/04 |
主分类号 |
A61K49/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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