Fremgangsmåder til behandling af cancerresistens over for ErbB-lægemider
摘要
Provided herein are methods for treating cancer that is resistant to treatment with an anti- ErbB therapeutic agent and which is associated with an activating MET gene mutation or a MET gene amplification. The methods involve administering to a subject a combination of an anti- ErbB therapeutic and an anti-MET therapeutic. Also provided are methods for reducing ErbB mediated signaling or PI3 kinase mediated signaling in a cancer cell.
申请公布号
DK2076289(T3)
申请公布日期
2015.02.09
申请号
DK20080742861T
申请日期
2008.04.11
申请人
DANA-FARBER CANCER INSTITUTE, INC.;BETH ISRAEL DEACONESS MEDICAL CENTER, INC.;THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL