STIMULATION REAGENT, CUTANEOUS SUBSTITUTE, CUTANEOUS EXPLANT AND METHOD FOR REPRODUCING THE PHYSIOPATHOLOGY OF ATOPIC DERMATITIS

摘要

The present invention relates to the use of a pro-inflammatory stimulating reagent containing between 10 and 500 ng/mL of interleukin IL-1&bgr; to reproduce the physiopathology of atopic dermatitis in vitro and/or to alter the barrier function in a cutaneous substitute or a cutaneous explant. It also relates to a pro-inflammatory stimulating reagent containing: a. Between 10 and 500 ng/mL interleukin IL-1&bgr;, and b. Between 3 and 20 µg/mL of a ligand of the TLR-2 receptor, and/or c. Between 3 and 20 µg/mL of a ligand of the TLR-3 receptor.