| 摘要 |
1,251,702. Amines. CIBA-GEIGY A.G. 22 April, 1969 [23 April, 1968; 3 Feb., 1969], No. 20521/69. Heading C2C. Compounds of the general formula (Ph= 1,2-phenylene; alk 1 = alkylene contributing 1-3 ring carbon atoms; B = alkylene or alkenylene contributing 4-6 ring carbon atoms; alk 2 = alkylene; Am = amino; or alk 2 + Am = azacycloalkyl, azacycloalkylalkyl, N-alkylazacycloalkylalkyl, wherein a heteroatom in the alk 2 group is separated from the nitrogen atom by at least two carbon atoms; R=H or OH), their 1-dehydro derivatives, acyl derivatives, N-oxides, quaternary compounds and salts are prepared by (a) replacing X in a compound of the formula by alk 2 Am or (b) reacting a compound of the formula with a tent.-aminoalkyl metal compound and hydrolysing the product, optionally followed by conversion of a 1-hydroxy compound to a 1-dehydro derivative and/or conversion to an acyl derivative, N-oxide, quaternary compound or salt, and/or resolution. The starting materials are prepared by standard methods. The above compounds are analgesics, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier. |
