| 摘要 |
The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of research, diagnostic and therapeutic purposes. STAT3 inhibitors, particularly LLL12, are disclosed. The STAT3 inhibitors are useful to treat breast cancer in general and breast cancer initiating cells in particular. |
| 主权项 |
1. A compound having the general formula I: wherein R1, R2 are independently hydrogen or alkyl M, wherein M is 1, 2, 3, 4, 5 or 6 carbons; R3, R5, R6, R8, R9 are independently hydrogen, alkyl, alkoxy, halogen, NO2, NH2, or hydroxyl; and R4, R7 are independently alkyl, alkoxy, O-alkyl, N-alkyl, aromatic, heteroaromatic, cyclic, or heterocyclic, except wherein R1, R2, R3, R4, R5, R7, R8 and R9 are each hydrogen and R6 is hydroxyl. |
